Journal article
Metformin use and preeclampsia risk in women with diabetes: a two-country cohort analysis
H Gordon, N Salim, S Tong, S Walker, M De Silva, C Cluver, P Mehdipour, R Hiscock, L Sutherland, A Doust, L Bergman, AK Wikström, A Lindquist, S Hesselman, R Hastie
BMC Medicine | BMC | Published : 2024
Abstract
Background: Metformin is a hypoglycaemic medication that has been proposed to treat or prevent preeclampsia. Combining national birth data from Scotland and Sweden, we investigated whether metformin used during pregnancy was associated with an altered risk of developing a hypertensive disorder of pregnancy. Methods: We utilised data from two population-based cohorts: Scotland (2012–2018) and Sweden (2007–2019). Nulliparous women with gestational diabetes or type 2 diabetes who had birth outcome data linked with medications prescribed during pregnancy were included. The association between metformin prescription and hypertensive disorders of pregnancy was characterised using inverse probabili..
View full abstractGrants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
HG is supported by a Postgraduate NHMRC Research Scholarship and an Australian Government Research Training Program Scholarship. RH (#1176922), ST (#1136418) and AL were all supported by the National Health and Medical Research Council. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. SH was supported by the Center for Clinical Research, Falun, Sweden (grant CKFUU-930828). LB was supported by the Wallenberg Center for Molecular and Translational Medicine.